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Individual differences in locomotor reactivity to a novel environment and sensitivity to opioid drugs in the rat. I. Expression of morphine-induced locomotor sensitization.

Authors
Type
Published Article
Journal
Psychopharmacology
Publication Date
Volume
177
Issue
1-2
Pages
61–67
Identifiers
PMID: 15316716
Source
Medline

Abstract

These results provide further evidence that phenotypic differences between HR and LR may, in part, be associated with differences in the endogenous opioid systems. Differences in sensitivity to acute versus repeated morphine suggest that at least in relation to opioid drugs, these phenotypes may reflect different aspects of drug vulnerability rather than simply the presence or absence of it.

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