Affordable Access

Individual cell migration serves as the driving force for optic vesicle evagination.

Authors
  • Rembold, Martina
  • Loosli, Felix
  • Adams, Richard J
  • Wittbrodt, Joachim
Type
Published Article
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
Aug 25, 2006
Volume
313
Issue
5790
Pages
1130–1134
Identifiers
PMID: 16931763
Source
Medline
License
Unknown

Abstract

The cellular mechanisms underlying organ formation are largely unknown. We visualized early vertebrate eye morphogenesis at single-cell resolution by in vivo imaging in medaka (Oryzias latipes). Before optic vesicle evagination, retinal progenitor cells (RPCs) modulate their convergence in a fate-specific manner. Presumptive forebrain cells converge toward the midline, whereas medial RPCs remain stationary, predetermining the site of evagination. Subsequent optic vesicle evagination is driven by the active migration of individual RPCs. The analysis of mutants demonstrated that the retina-specific transcription factor rx3 determines the convergence and migration behaviors of RPCs. Hence, the migration of individual cells mediates essential steps of organ morphogenesis.

Report this publication

Statistics

Seen <100 times