Increasing the chemical potential of the germ-line antibody repertoire.

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Increasing the chemical potential of the germ-line antibody repertoire.

Publication Date
May 01, 1993
Source
PMC
Keywords
Disciplines
  • Chemistry
  • Medicine
License
Unknown

Abstract

To augment the chemical potential of the immunological repertoire, a metal ion-binding light chain has been introduced into the murine genome. Mice containing the transgene were subsequently immunized with a fluorescein conjugate. The transgenic light chain was found at a high frequency in the anti-fluorescein memory B-cell compartment. This general method should be applicable to other cofactors and small molecules and should lead to generation of antibodies with unique catalytic activities.

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