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Increasing plasma potassium with amiloride shortens the QT interval and reduces ventricular extrasystoles but does not change endothelial function or heart rate variability in chronic heart failure

Authors
Publisher
Copyright 2002 by Heart
Publication Date
Source
PMC
Keywords
Disciplines
  • Biology
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Unknown

Abstract

Objectives: To test whether simply increasing plasma potassium with amiloride would exert any of the same beneficial effects on “surrogate outcome measures” that are seen with spironolactone. The latter has been shown to improve mortality in chronic heart failure, possibly as a result of improvements in endothelial dysfunction, vascular angiotensin converting enzyme (ACE), autonomic function, myocardial fibrosis, ventricular arrhythmias, and QT interval indices.

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