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Increasing the isolated quantities and purities of volatile compounds by using a triple Deans-switch multidimensional preparative gas chromatographic system with an apolar-wax-ionic liquid stationary-phase combination.

Authors
  • Sciarrone, Danilo
  • Pantò, Sebastiano
  • Ragonese, Carla
  • Tranchida, Peter Quinto
  • Dugo, Paola
  • Mondello, Luigi
Type
Published Article
Journal
Analytical Chemistry
Publisher
American Chemical Society
Publication Date
Aug 21, 2012
Volume
84
Issue
16
Pages
7092–7098
Identifiers
DOI: 10.1021/ac3013829
PMID: 22835067
Source
Medline
License
Unknown

Abstract

A novel preparative-scale triple gas chromatographic system, equipped with three Deans-switch devices, is herein described. The isolation of volatile compounds was achieved by using a lab-made collection system. Considerations are made on the possibility to inject high volumes of neat sample, maintaining, at the same time, high resolution levels. The degree of recovery of a series of compounds, characterized by a differing volatility, is also reported. In this respect, different collection conditions were evaluated, namely, the presence (or not) of packing material as well as CO(2) cooling, in various combinations. Finally, the interconnected features, that is time requirements and the isolation of "acceptable" analyte quantities (e.g., milligram level for NMR characterization), are related to parameters such as analyte concentration, injected volume, collection conditions, and number of GC runs. The results herein reported will demonstrate the need for a high-resolution GC step, prior to analyte collection, in the prep-GC analysis of complex samples.

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