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Increases in myocardial workload induced by rapid atrial pacing trigger alterations in global metabolism.

Authors
  • Turer, Aslan T
  • Lewis, Gregory D
  • O'Sullivan, John F
  • Elmariah, Sammy
  • Mega, Jessica L
  • Addo, Tayo A
  • Sabatine, Marc S
  • de Lemos, James A
  • Gerszten, Robert E
Type
Published Article
Journal
PLoS ONE
Publisher
Public Library of Science
Publication Date
Jan 01, 2014
Volume
9
Issue
6
Identifiers
DOI: 10.1371/journal.pone.0099058
PMID: 24932507
Source
Medline
License
Unknown

Abstract

Isolated increases in myocardial work can induce changes in the plasma metabolome, but these changes do not appear to be directly cardiac in origin. A number of these dynamic metabolites have known signaling functions. Our study provides additional evidence to a growing body of literature on metabolic 'cross-talk' between the heart and other organs.

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