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[Increases in the activity of lysosomal DNAase in mouse liver during the development of Friend's viral leukemia].

Authors
  • Drozhennikov, V A
  • Perevezentseva, O S
  • Orlova, E B
Type
Published Article
Journal
Biokhimii︠a︡ (Moscow, Russia)
Publication Date
Apr 01, 1979
Volume
44
Issue
4
Pages
649–657
Identifiers
PMID: 435576
Source
Medline
License
Unknown

Abstract

A developing Friend's viral leukemia is accompanied by a 2,0--2,5-fold increase in the activity of lysosomal DNAse (DNAse II) in mouse liver as compared to normal. The increase in activity is observed on the 10--12th day after inoculation of virus-containing material and reaches its maximum on the 20th post-inoculation day. The increase in DNAse II activity is due to activation of the lysosomal system of Kupffer's and endothelial cells of the liver. The activity of mitochondrial DNAse (DNAse I) in the livers of leukemic mice showed no deviations from the normal level. A possible role of DNAse II in the protective response of the organism is discussed.

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