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[Increased synthesis of extracellular matrix in passaged nucleus pulposus cells by transfection with adenoviral vectors containing human transforming growth factor beta1].

Authors
  • Li, Xu
  • Hou, Xiaokui
  • Tang, Tingting
Type
Published Article
Journal
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Publication Date
Dec 01, 2007
Volume
21
Issue
12
Pages
1342–1347
Identifiers
PMID: 18277681
Source
Medline
License
Unknown

Abstract

To a greater extent, hTGF-beta1 can play a key role in maintaining the phenotype of the NP cells and can still have an effect of the phenotypic modulation after a serial of the cell passages. The NP cells that are genetically manipulated to express hTGF-beta1 have a promising effect on the restoration of the intervertebral disc defects. The NP cells transfected with Ad/ hTGF-beta1 cultured in the 3-D alginate bead systems can show a nearly native phenotype.

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