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Increased synaptic availability of norepinephrine following desipramine is not essential for increases in GR mRNA. Short communication.

Authors
  • Eiring, A
  • Sulser, F
Type
Published Article
Journal
Journal of neural transmission (Vienna, Austria : 1996)
Publication Date
Jan 01, 1997
Volume
104
Issue
11-12
Pages
1255–1258
Identifiers
PMID: 9503270
Source
Medline
License
Unknown

Abstract

Male Sprague-Dawley rats were treated for 7 days with the norepinephrine (NE) uptake inhibitors desipramine (DMI) or (+)-oxaprotiline or the inactive (-)-enantiomer of oxaprotiline. DMI, as previously reported, significantly increased hippocampal glucocorticoid receptor (GR) mRNA while the equipotent NE uptake inhibitor (+)-oxaprotiline like the inactive (-)-oxaprotiline did not alter hippocampal levels of GR mRNA. The results indicate that an increase in the synaptic availability of NE as a consequence of uptake inhibition is not responsible for the action of DMI on GR gene expression.

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