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Increased sodium influx and calcium uptake in erythrocytes in hyperthyroidism: role of abnormal membrane lipid levels.

Authors
  • De Riva, C
  • Virgili, F
  • Frigato, F
Type
Published Article
Journal
Metabolism
Publisher
Elsevier
Publication Date
Jun 01, 1996
Volume
45
Issue
6
Pages
707–711
Identifiers
PMID: 8637444
Source
Medline
License
Unknown

Abstract

The study was designed to examine the effects of thyroid hormones on red blood cell (RBC) membrane phospholipids and ion transport. We demonstrated that in untreated Graves' disease, an alteration in the phospholipid pattern is present at cellular levels, with a concomitant derangement in membrane permeability defined as (22)Na influx and (45)Ca uptake. Thionamide therapy replaced the normal membrane permeability, presumably as a consequence of restoring the normal phospholipid membrane composition. We conclude that thyroid hormones are able to induce a quick breakdown of a large number of membrane components such as membrane phospholipids.

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