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Increased serum levels of galectin-9 in patients with chikungunya fever.

Authors
  • Gualberto Cavalcanti, Nara1
  • Melo Vilar, Kamila2
  • Branco Pinto Duarte, Angela Luzia3
  • Barreto de Melo Rêgo, Moacyr Jesus4
  • Pereira, Michelly Cristiny5
  • da Rocha Pitta, Ivan4
  • Diniz Lopes Marques, Claudia6
  • Galdino da Rocha Pitta, Maira4
  • 1 Rheumatology Department, Hospital das Clínicas, Universidade Federal de Pernambuco (UFPE), Brazil; Programa de Pós-Graduação em Inovação Terapêutica (PPGIT)/ UFPE, Brazil. Electronic address: [email protected] , (Brazil)
  • 2 Programa de Pós-Graduação em Inovação Terapêutica (PPGIT)/ UFPE, Brazil. , (Brazil)
  • 3 Rheumatology Department, Hospital das Clínicas, Universidade Federal de Pernambuco (UFPE), Brazil; Programa de Pós-Graduação em Inovação Terapêutica (PPGIT)/ UFPE, Brazil. , (Brazil)
  • 4 Programa de Pós-Graduação em Inovação Terapêutica (PPGIT)/ UFPE, Brazil; Núcleo de Pesquisa em Inovação Terapêutica - Sueli Galdino (Nupit-SG), Brazil. , (Brazil)
  • 5 Núcleo de Pesquisa em Inovação Terapêutica - Sueli Galdino (Nupit-SG), Brazil; Pharmacology and Physiology Department/ UFPE, Brazil. , (Brazil)
  • 6 Rheumatology Department, Hospital das Clínicas, Universidade Federal de Pernambuco (UFPE), Brazil. , (Brazil)
Type
Published Article
Journal
Virus research
Publication Date
Sep 01, 2020
Volume
286
Pages
198062–198062
Identifiers
DOI: 10.1016/j.virusres.2020.198062
PMID: 32565125
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Chikungunya fever (CHIKF) is an arboviral disease that has caused an epidemic burst of chronic inflammatory joint disease in Latin America in the last few years. Efforts are being spent in understanding the mechanisms by which it may cause such articular damage and in determining possible biomarkers of the disease. Galectins (GAL) are a family of animal lectins with an affinity for beta-galactosides. They have multiple functions including working as receptors in innate immunity and as a control for inflammatory responses in both innate and adaptive immunity. They regulate functions of immune cells, such as lymphocytes and macrophages, which have a main role in the chikungunya inflammatory process. Galectins are also involved in chronification of viral diseases, participate in the immunopathogenesis of chronic joint diseases such as rheumatoid arthritis, and have a role in inflammation in other arboviral diseases, such as dengue. Thus, we intended to determine the serum levels of galectin-1, -3, -4, -7, and -9 in patients with subacute and chronic articular manifestations of CHIKF and to evaluate their associations with clinical manifestations. We evaluated 44 patients with clinical manifestations of CHIKF and serological confirmation with IgM and/or IgG chikungunya virus (CHIKV) antibodies. Forty-nine age- and gender-matched healthy individuals served as controls. Anti-CHIKV IgM and IgG antibodies and galectins serum levels were measured by ELISA. We found higher levels of GAL-9 (patients median 2192 [1500-2631] pg/mL, controls median 46.88 [46.88-46.88] pg/mL, p < 0.0001) and lower levels of GAL-3 (patients median 235.5 [175.5-351.8] pg/mL, controls median 2236.0 [1256.0-2236.0] pg/mL, p < 0.0001) in patients than in controls. There was no statistical difference in levels of GAL-1, -4 and -7 between patients and control groups. There was no difference in GAL-9 serum levels between patients with subacute or chronic symptoms (median 2148 [1500-2722] pg/mL x 2212 [1844-2500] pg/mL, p = 0.3626). A significant association of GAL-9 with joint stiffness, both in its duration and intensity, was found. These results may reflect the participation of GAL-9 in the immunopathogenesis of the inflammatory process in chikungunya fever, as morning stiffness may reflect the systemic inflammatory process. Copyright © 2020 Elsevier B.V. All rights reserved.

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