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Increased sarcoma virus RNA in cells transformed by leukemia viruses: model for leukemogenesis.

Authors
  • Peebles, P T
  • Scolnick, E M
  • Howk, R S
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Jun 11, 1976
Volume
192
Issue
4244
Pages
1143–1145
Identifiers
PMID: 179144
Source
Medline
License
Unknown

Abstract

A morphologically flat revertant of mink cells nonproductively infected with Moloney sarcoma virus exhibited contact inhibition and lacked detectable sarcoma virus RNA. Superinfection by usually nontransforming type C mammalian leukemia-causing viruses induced transformation and increased sarcoma virus RNA. The results suggest a model for leukemogenesis in animals by increasing, during replication of usually nontransforming leukemia viruses, the levels of RNA from potentially oncogenic cell or integrated virus transforming genes.

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