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Increased protein C and fibrinopeptide A concentration in patients with angina.

Authors
  • Gensini, G F
  • Rostagno, C
  • Abbate, R
  • Favilla, S
  • Mannucci, P M
  • Neri Serneri, G G
Type
Published Article
Journal
Thrombosis Research
Publisher
Elsevier
Publication Date
May 15, 1988
Volume
50
Issue
4
Pages
517–525
Identifiers
PMID: 3413718
Source
Medline
License
Unknown

Abstract

Protein C and fibrinopeptide A (FpA) levels in plasma were measured in 30 controls and in two groups of patients with angina. The first group was formed by 27 patients suffering from spontaneous ischemic attacks (active angina). The second one was formed by patients who had previously suffered from angina, but were free from myocardial ischemic attacks for at least one month (inactive angina). Protein C (measured by electroimmunoassay) and FpA (radioimmunoassay) were higher than controls in both groups but were significantly higher in patients with active angina than in patients with inactive angina. A clear trend toward a linear correlation existed between protein C and FpA levels, though it did not reach the statistical significance. These results confirm a significant involvement of blood clotting system in ischemic heart disease and specially in active angina.

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