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Increased peripheral lymphocytes, lymphoid hepatitis and anaemia in African vervet monkeys seropositive to retroviruses.

Authors
  • Fincham, J E1
  • Van der Riet, F
  • Steytler, J G
  • Tung, M T
  • Cooper, R
  • Seier, J V
  • Madden, D L
  • Kanki, P
  • Campbell, J A
  • Taljaard, J J
  • 1 Research Institute for Nutritional Diseases of the South African Medical Research Council, Tygerberg. , (South Africa)
Type
Published Article
Journal
Journal of comparative pathology
Publication Date
Jul 01, 1989
Volume
101
Issue
1
Pages
53–68
Identifiers
PMID: 2551937
Source
Medline
License
Unknown

Abstract

Wild-caught African Vervet monkeys are commonly infected by Simian T-lymphotropic virus I (STLV1) and Simian immunodeficiency virus (SIV), yet the natural histories of these infections are largely unknown. Seropositivity was associated with increased total, T and atypical lymphocytes. In seropositive females there was mild, normocytic, normochromic anaemia. Lymphoid hepatitis was present in seven seropositive cases. African Vervets used in biomedical research, vaccine production and organ transplantation research are often infected by exogenous retroviruses which can be oncogenic and immunosuppressive in captive monkeys. Elimination of these infections may be possible by breeding Vervets in captivity.

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