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Increased omega complexity and decreased microstate duration in nonmedicated schizophrenic patients.

Authors
  • Irisawa, Satoshi
  • Isotani, Toshiaki
  • Yagyu, Takami
  • Morita, Sachi
  • Nishida, Keiichiro
  • Yamada, Keizo
  • Yoshimura, Masafumi
  • Okugawa, Gaku
  • Nobuhara, Kenji
  • Kinoshita, Toshihiko
Type
Published Article
Journal
Neuropsychobiology
Publication Date
Jan 01, 2006
Volume
54
Issue
2
Pages
134–139
Identifiers
PMID: 17199099
Source
Medline
License
Unknown

Abstract

To explore brain functions in schizophrenic patients, the global analytic strategy of multichannel EEG was performed that combines measures of global complexity (Omega), total power (Sigma) and generalized frequency (Phi), and EEG microstate analysis was applied to multichannel EEG data for 24 nonmedicated patients and 24 healthy subjects. The patients had higher Omega and Sigma values, and lower Phi values compared with healthy subjects. Three topographical classes were obtained from all EEG data by EEG microstate analysis. The mean duration of one topographical class in the patients was shortened compared to healthy subjects. These results indicated looser cooperativity, or decreased connectivity of the active brain process and deviant brain information processing in schizophrenic patients.

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