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Increased muscarinic cholinergic receptors in prefrontal cortices of medicated schizophrenics.

Authors
  • Watanabe, S
  • Nishikawa, T
  • Takashima, M
  • Toru, M
Type
Published Article
Journal
Life Sciences
Publisher
Elsevier
Publication Date
Nov 28, 1983
Volume
33
Issue
22
Pages
2187–2196
Identifiers
PMID: 6139728
Source
Medline
License
Unknown

Abstract

Alterations in 3H-quinuclidinyl benzilate binding sites associated with muscarinic cholinergic receptors were investigated in orbito-frontal and medial frontal cortices from 12 schizophrenics, 6 on-drug and 6 off-drug cases, and from 10 controls. Significantly lower affinities of the sites were found in both areas of schizophrenics than controls. An increase in receptor number was shown only in the orbito-frontal cortex from schizophrenics. On-drug group of schizophrenics did, however, show a significant increase in receptor number and a significant decrease in affinity in both areas, while there were no significant differences in any binding parameters of off-drug schizophrenics from controls. Also in the caudate the similar results were obtained. It is, thus, concluded that alterations in muscarinic cholinergic receptors of schizophrenic patients result from long-term medication with antimuscarinic actions.

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