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Increased mesolimbic dopamine binding following chronic haloperidol treatment.

Authors
Type
Published Article
Journal
Psychopharmacology
Publication Date
Volume
72
Issue
3
Pages
261–263
Identifiers
PMID: 6784143
Source
Medline

Abstract

It is well documented that chronic neuroleptic treatment creates a dopamine receptor supersensitivity in the striatum. The present study examined the effect of chronic neuroleptic treatment on mesolimbic dopamine receptor binding. Rats received either 0.5 mg/kg of haloperidol, 50 mg/kg of sodium phenobarbital, or 0.9% saline daily for 21 days. One week following the last injection, the rats were sacrificed and the septi were removed for the 3H-dopamine binding assay. Haloperidol treatment resulted in a 52% increase in 3H-dopamine binding in the septum, whereas phenobarbital treatment caused no significant change.

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