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Increased levels of serum pentraxin 3, a novel cardiovascular biomarker, in patients with inflammatory rheumatic disease.

Authors
  • Hollan, Ivana
  • Bottazzi, Barbara
  • Cuccovillo, Ivan
  • Førre, Øystein T
  • Mikkelsen, Knut
  • Saatvedt, Kjell
  • Almdahl, Sven Martin
  • Mantovani, Alberto
  • Meroni, Pier Luigi
Type
Published Article
Journal
Arthritis Care & Research
Publisher
Wiley (John Wiley & Sons)
Publication Date
Mar 01, 2010
Volume
62
Issue
3
Pages
378–385
Identifiers
DOI: 10.1002/acr.20094
PMID: 20391484
Source
Medline
License
Unknown

Abstract

CAD patients with IRD had higher mean serum PTX3 levels than patients without IRD and healthy controls. In addition, acute coronary syndromes and low alcohol intake independently predicted higher serum PTX3 levels. Higher serum PTX3 levels in IRD may be related to the higher cardiovascular risk of IRD patients. Circulating PTX3 could likely be used as a biomarker for severity of cardiovascular disease in IRDs; its importance, however, might be limited in SLE and related disorders.

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