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Increased inflammatory reaction to intestinal ischemia-reperfusion in neonatal versus adult mice.

Authors
  • Yu, Yi
  • Klemann, Christian
  • Feng, Xiaoyan
  • Ginzel, Marco
  • Vieten, Gertrud
  • Lacher, Martin
  • Ure, Benno
  • Kuebler, Joachim F
Type
Published Article
Journal
European Journal of Pediatric Surgery
Publisher
Georg Thieme Verlag KG
Publication Date
Feb 01, 2015
Volume
25
Issue
1
Pages
46–50
Identifiers
DOI: 10.1055/s-0034-1387945
PMID: 25422903
Source
Medline
License
Unknown

Abstract

The intestines of neonatal mice reacted with an increased inflammatory response to the ischemic insult. This increased susceptibility could help to explain the exaggerated inflammation seen in diseases such as necrotizing enterocolitis.

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