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Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer’s Disease Patients

Authors
  • Metaxas, Athanasios1
  • Thygesen, Camilla1
  • Briting, Sanne R. R.1
  • Landau, Anne M.2, 3
  • Darvesh, Sultan4, 5
  • Finsen, Bente1
  • 1 Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense , (Denmark)
  • 2 Translational Neuropsychiatry Unit, Aarhus University, Aarhus , (Denmark)
  • 3 Department of Nuclear Medicine and PET-Center, Aarhus University, Aarhus , (Denmark)
  • 4 Department of Medical Neuroscience, Dalhousie University, Halifax, NS , (Canada)
  • 5 Department of Medicine, Neurology, and Geriatric Medicine, Dalhousie University, Halifax, NS , (Canada)
Type
Published Article
Journal
Frontiers in Cellular Neuroscience
Publisher
Frontiers Media SA
Publication Date
Dec 05, 2019
Volume
13
Identifiers
DOI: 10.3389/fncel.2019.00538
PMID: 31866830
PMCID: PMC6906198
Source
PubMed Central
Keywords
License
Unknown

Abstract

Sections from the middle frontal gyrus (Brodmann area 46) of autopsy-confirmed Alzheimer’s disease (AD) patients and non-demented subjects were examined for the prevalence of hallmark AD pathology, including amyloid-β (Aβ) plaques, phosphorylated tau (pTau) tangles, neuroinflammation and synaptic loss ( n = 7 subjects/group). Dense-core deposits of Aβ were present in all AD patients (7/7) and some non-demented subjects (3/7), as evidenced by 6E10 immunohistochemistry. Levels of Aβ immunoreactivity were higher in AD vs. non-AD cases. For pTau, AT8-positive neurofibrillary tangles and threads were exclusively observed in AD patient tissue. Levels of [3H]PK11195 binding to the translocator protein (TSPO), a marker of inflammatory processes, were elevated in the gray matter of AD patients compared to non-demented subjects. Levels of [3H]UCB-J binding to synaptic vesicle glycoprotein 2A (SV2A), a marker of synaptic density, were not different between groups. In AD patients, pTau immunoreactivity was positively correlated with [3H]PK11195, and negatively correlated with [3H]UCB-J binding levels. No correlation was observed between Aβ immunoreactivity and markers of neuroinflammation or synaptic density. These data demonstrate a close interplay between tau pathology, inflammation and SV2A density in AD, and provide useful information on the ability of neuroimaging biomarkers to diagnose AD dementia.

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