Increased human tumor necrosis factor-α levels induce procoagulant change in porcine endothelial cells in vitro.
Division of Biotechnology, Korea University College of Life Sciences and Biotechnology, Seoul, Korea.
- Published Article
- Publication Date
Jan 01, 2012
Human TNFα level increases in human blood after contact with PECs, which is attributed to xenoreactive antibody binding and subsequent complement activation. Human TNFα induces procoagulant changes in PECs with increased TF expression. This study suggests that human TNFα may be one of the mediators linking complement activation with procoagulant changes in the xenoendothelium.
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This record was last updated on 06/09/2018 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/22702470