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Increased human tumor necrosis factor-α levels induce procoagulant change in porcine endothelial cells in vitro.

Authors
Type
Published Article
Journal
Xenotransplantation
Publication Date
Volume
19
Issue
3
Pages
186–195
Identifiers
DOI: 10.1111/j.1399-3089.2012.00704.x
PMID: 22702470
Source
Medline

Abstract

Human TNFα level increases in human blood after contact with PECs, which is attributed to xenoreactive antibody binding and subsequent complement activation. Human TNFα induces procoagulant changes in PECs with increased TF expression. This study suggests that human TNFα may be one of the mediators linking complement activation with procoagulant changes in the xenoendothelium.

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