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Increased human tumor necrosis factor-α levels induce procoagulant change in porcine endothelial cells in vitro.

Authors
  • Lee, Kyoung Geun1
  • Lee, Haneulnari
  • Ha, Jeong Mi
  • Lee, Young Kyung
  • Kang, Hee Jung
  • Park, Chung-Gyu
  • Kim, Sang Joon
  • 1 Division of Biotechnology, Korea University College of Life Sciences and Biotechnology, Seoul, Korea. , (North Korea)
Type
Published Article
Journal
Xenotransplantation
Publication Date
Jan 01, 2012
Volume
19
Issue
3
Pages
186–195
Identifiers
DOI: 10.1111/j.1399-3089.2012.00704.x
PMID: 22702470
Source
Medline
License
Unknown

Abstract

Human TNFα level increases in human blood after contact with PECs, which is attributed to xenoreactive antibody binding and subsequent complement activation. Human TNFα induces procoagulant changes in PECs with increased TF expression. This study suggests that human TNFα may be one of the mediators linking complement activation with procoagulant changes in the xenoendothelium.

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