Affordable Access

Increased frequencies of Sm and nRNP autoantibodies in American blacks compared to whites with systemic lupus erythematosus.

Authors
  • Arnett, F C
  • Hamilton, R G
  • Roebber, M G
  • Harley, J B
  • Reichlin, M
Type
Published Article
Journal
The Journal of rheumatology
Publication Date
Dec 01, 1988
Volume
15
Issue
12
Pages
1773–1776
Identifiers
PMID: 3230562
Source
Medline
License
Unknown

Abstract

Frequencies of autoantibodies to Sm, nRNP, Ro (SSA) and La (SSB) were determined by countercurrent immunoelectrophoresis (CIE) and/or enzyme linked immunosorbent assays (ELISA) in 106 whites and 60 blacks with systemic lupus erythematosus. Anti-Sm occurred significantly more frequently in blacks (25%) than whites (10%) (p = 0.02), as did anti-nRNP (40% versus 23%; p = 0.03). By CIE, anti-Sm and/or nRNP occurred in 47% of blacks and 24% of whites (p = 0.004), and by ELISA the Sm/nRNP complex was detected in 52% of blacks versus 26% of whites (p = 0.003). Antibodies to Ro and La occurred with equal frequencies between the races.

Report this publication

Statistics

Seen <100 times