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Increased exercise tolerance with nitrates in beta-blockaded patients with angina.

Authors
  • R H Baxter
  • I M Lennox
Publication Date
Aug 27, 1977
Source
PMC
Keywords
License
Unknown

Abstract

In 14 beta-blockaded anginal subjects, 10 of whom had poor left ventricular function, sublingual isosorbide dinitrate significantly increased maximal exercise capacity on a standardized multistage treadmill test. This was associated with changes in heart rate and blood pressure suggestive of a fall in left ventricular work. The effect of isosorbide lasts for at least two hours and when taken before exercise may be a useful addition to beta-blockade in patients with angina.

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