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Increased DHT levels in androgenic alopecia have been selected for to protect men from prostate cancer

Authors
  • Bhargava, Shiva1
  • 1 Cornell University
Type
Published Article
Journal
Medical Hypotheses
Publisher
Elsevier
Publication Date
Jan 01, 2014
Accepted Date
Jan 18, 2014
Volume
82
Issue
4
Pages
428–432
Identifiers
DOI: 10.1016/j.mehy.2014.01.016
Source
Elsevier
License
Unknown

Abstract

Androgenic alopecia, a condition characterized by increased levels of DHT could have been selected for due to the benefits that prostaglandin D2 (PGD2) has on the prostate. A DHT metabolite can increase the transcription of prostaglandin D2 synthase through estrogen receptor beta. The increase of PGD2 can decrease the risk of prostate cancer and proliferation of prostate cancer cells. Therefore, the mechanisms behind male pattern baldness may also curtail the advancement of prostate cancer.

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