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Increased cell size and Akt activation in HER-2/neu-overexpressing invasive ductal carcinoma of the breast.

Authors
  • Sastre-Garau, X
  • Genin, P
  • Rousseau, A
  • Al Ghuzlan, A
  • Nicolas, A
  • Fréneaux, P
  • Rosty, C
  • Sigal-Zafrani, B
  • Couturier, J
  • Thiery, J-P
  • Magdelénat, H
  • Vincent-Salomon, A
Type
Published Article
Journal
Histopathology
Publication Date
Aug 01, 2004
Volume
45
Issue
2
Pages
142–147
Identifiers
PMID: 15279632
Source
Medline
License
Unknown

Abstract

HER-2/neu overexpression was consistently associated with increased cell size in invasive ductal carcinoma of the breast. This increase may be related to concomitant Akt activation. The assessment of activated pathways in HER-2/neu-overexpressing breast carcinomas may provide useful information for optimized individual HER-2/neu-targeted therapy.

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