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Increased brain damage after ischaemic stroke in mice lacking the chemokine receptor CCR5.

Authors
  • Sorce, S
  • Bonnefont, J
  • Julien, S
  • Marq-Lin, N
  • Rodriguez, I
  • Dubois-Dauphin, M
  • Krause, K H
Type
Published Article
Journal
British Journal of Pharmacology
Publisher
Wiley (Blackwell Publishing)
Publication Date
May 01, 2010
Volume
160
Issue
2
Pages
311–321
Identifiers
DOI: 10.1111/j.1476-5381.2010.00697.x
PMID: 20423342
Source
Medline
License
Unknown

Abstract

Lack of CCR5 increased the severity of brain injury following occlusion of the middle cerebral artery. This is of particular interest with respect to the relatively frequent occurrence of CCR5 deficiency in the human population (1-2% of the Caucasian population) and the advent of CCR5 inhibitors as novel drugs.

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