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Increased anti-Helicobacter pylori effect of the probiotic Lactobacillus fermentum UCO-979C strain encapsulated in carrageenan evaluated in gastric simulations under fasting conditions.

Authors
  • Gutiérrez-Zamorano, Cristian1
  • González-Ávila, Marisela2
  • Díaz-Blas, Gustavo1
  • Smith, Carlos T1
  • González-Correa, Carlos1
  • García-Cancino, Apolinaria3
  • 1 Departamento de Microbiología, Universidad de Concepción, Concepción, Chile. , (Chile)
  • 2 Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C. Guadalajara, Mexico. , (Mexico)
  • 3 Departamento de Microbiología, Universidad de Concepción, Concepción, Chile. Electronic address: [email protected] , (Chile)
Type
Published Article
Journal
Food research international (Ottawa, Ont.)
Publication Date
Jul 01, 2019
Volume
121
Pages
812–816
Identifiers
DOI: 10.1016/j.foodres.2018.12.064
PMID: 31108812
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Helicobacter pylori, a gastric carcinogenic pathogen, colonizes the stomach of 50% of the human population and is considered as a WHO priority 2 due to its antibiotics resistance. Therefore, research should aim to avoid H. pylori infection. Probiotics are an emerging alternative to handle this pathogen, making it necessary to have means to evaluate their effectiveness. This work evaluated the effect of a carrageenan encapsulated probiotic, Lactobacillus fermentum UCO-979C strain, against the pathogenic H. pylori SS1 strain under simulated gastric conditions (fasting or standard diet, pH 3.0 under microaerophilic condition and agitation). Samples were obtained from simulators up to 2.5 h after adding the probiotic, either planktonic or carrageenan encapsulated, and H. pylori were counted using enriched Columbia agar. Gastric simulations under fasting or standard diet showed collaboration between L. fermentum and carrageenan against the pathogen, it is undetectable at 1.5 or 2.5 h, respectively, allowing to conclude that the administration of the probiotic under fasting (harsher acid environment) provides a better anti-H. pylori effect that administering it associated with the diet. Thus, it can be suggested to consume low pH resistant probiotics under fasting. Copyright © 2018. Published by Elsevier Ltd.

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