Increase in sex-dependent expression of prolactin receptors after intrahepatic transplantation of H27 rat hepatoma cells.
Laboratory of Endocrinology, Department of Biophysics, Biological Faculty, M. V. Lomonosov Moscow State University. [email protected]
- Published Article
Bulletin of experimental biology and medicine
- Publication Date
Mar 01, 2007
Immunohistochemical study revealed overexpression of prolactin receptors in central and peripheral cells of intrahepatic grafts from H27 rat hepatoma without changes in compartmentalization compared to hepatocytes of intact animals. Experiments with gonadectomized animals showed that the hormonal regulation of prolactin receptors in both types of tumor cells does not differ from that in normal liver cells (positive estrogen-dependent regulation and negative androgen-dependent regulation).
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/18225749