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Increase of beta-endorphin levels in cerebrospinal fluid but not in plasma in patients with cerebral infarction.

Authors
  • Furui, T
  • Satoh, K
  • Asano, Y
  • Shimosawa, S
  • Hasuo, M
  • Yaksh, T L
Type
Published Article
Journal
Journal of neurosurgery
Publication Date
Oct 01, 1984
Volume
61
Issue
4
Pages
748–751
Identifiers
PMID: 6088732
Source
Medline
License
Unknown

Abstract

beta-Endorphin was measured in cerebrospinal fluid (CSF) and plasma in patients with cerebral infarction at acute (4 to 48 hours) and chronic (1 month) stages. Only CSF samples obtained in the acute stage showed beta-endorphin values that were statistically higher than those measured in a control population. This finding suggests that infarction at its acute stage gives rise to an increased release of beta-endorphin. Such a mechanism is consistent with the possibility that the reported therapeutic effect of naloxone in cerebral ischemic lesions may result in part from the antagonism of the centrally released endorphin, beta-endorphin.

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