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Incorporation of FGF-2 into Pharmaceutical Grade Fucoidan/Chitosan Polyelectrolyte Multilayers

Authors
  • Benbow, Natalie L.1
  • Karpiniec, Samuel2
  • Krasowska, Marta1
  • Beattie, David A.1
  • 1 Future Industries Institute, University of South Australia, Mawson Lakes, SA 5095, Australia
  • 2 Marinova, Cambridge, TAS 7170, Australia
Type
Published Article
Journal
Marine Drugs
Publisher
MDPI AG
Publication Date
Oct 26, 2020
Volume
18
Issue
11
Identifiers
DOI: 10.3390/md18110531
PMID: 33114688
PMCID: PMC7692699
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Green

Abstract

Biopolymer polyelectrolyte multilayers are a commonly studied soft matter system for wound healing applications due to the biocompatibility and beneficial properties of naturally occurring polyelectrolytes. In this work, a popular biopolymer, chitosan, was combined with the lesser known polysaccharide, fucoidan, to create a multilayer film capable of sequestering growth factor for later release. Fucoidan has been shown to act as a heparin-mimic due to similarities in the structure of the two molecules, however, the binding of fibroblast growth factor-2 to fucoidan has not been demonstrated in a multilayer system. This study assesses the ability of fucoidan to bind fibroblast growth factor-2 within a fucoidan/chitosan polyelectrolyte multilayer structure using attenuated total internal reflectance infrared spectroscopy and quartz crystal microbalance with dissipation monitoring. The fibroblast growth factor-2 was sequestered into the polyelectrolyte multilayer as a cationic layer in the uppermost layers of the film structure. In addition, the diffusion of fibroblast growth factor-2 into the multilayer has been assessed.

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