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Inclusion of memory effects in a dynamic model of electroporation in biological tissues.

Authors
  • Weinert, Rodolfo1
  • Pereira, Eduardo1
  • Ramos, Airton1
  • 1 Universidade do Estado de Santa Catarina Ringgold Standard Institution, Electrical Engineering, Joinville, Brazil. , (Brazil)
Type
Published Article
Journal
Artificial organs
Publication Date
Jul 01, 2019
Volume
43
Issue
7
Pages
688–693
Identifiers
DOI: 10.1111/aor.13415
PMID: 30589443
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

This article presents experimental and computational results of electroporation in rat liver. The experiments were performed using different forms of electrodes and waveforms of applied electric pulses. For the numerical simulation, the electroporation model proposed by Ramos and Weinert in a previous publication was used. Dynamic adjustments were used for obtaining a good modeling of the electric current. A single set of model parameters was obtained to fit the simulated current response for different waveforms and electrodes. These parameters were obtained with the use of a genetic algorithm that minimized the error between the simulated and experimental currents. The electroporation model with dynamic adjustment proved to be an appropriate simulation tool to predict the tissue conductivity during stimulation by intense electrical fields. © 2019 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

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