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Incidence, risk factors, and impact of severe neutropenia after hyperthermic intraperitoneal mitomycin C.

Authors
  • Lambert, Laura A1
  • Armstrong, Terri S
  • Lee, J Jack
  • Liu, Suyu
  • Katz, Matthew H G
  • Eng, Cathy
  • Wolff, Robert A
  • Tortorice, Melissa L
  • Tansey, Pier
  • Gonzalez-Moreno, Santiago
  • Lambert, Donald H
  • Mansfield, Paul F
  • 1 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [email protected]
Type
Published Article
Journal
Annals of Surgical Oncology
Publisher
Springer - Society of Surgical Oncology
Publication Date
August 2009
Volume
16
Issue
8
Pages
2181–2187
Identifiers
DOI: 10.1245/s10434-009-0523-4
PMID: 19475451
Source
Medline
License
Unknown

Abstract

Neutropenia is a frequent complication associated with MMC-HIPEC. Female sex and MMC dose per BSA are independent risk factors for neutropenia. These differences must be considered in the management of patients undergoing MMC-HIPEC to minimize the toxicity of the procedure.

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