Affordable Access

deepdyve-link
Publisher Website

Incidence, prevalence, natural course and prognosis of patellofemoral osteoarthritis: the Cohort Hip and Cohort Knee study.

Authors
  • Lankhorst, N E1
  • Damen, J1
  • Oei, E H2
  • Verhaar, J A N3
  • Kloppenburg, M4
  • Bierma-Zeinstra, S M A5
  • van Middelkoop, M6
  • 1 Department of General Practice, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands. , (Netherlands)
  • 2 Department of Radiology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands. , (Netherlands)
  • 3 Department of Orthopaedics, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands. , (Netherlands)
  • 4 Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands; Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands. , (Netherlands)
  • 5 Department of General Practice, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands; Department of Radiology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands. , (Netherlands)
  • 6 Department of General Practice, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands. Electronic address: [email protected] , (Netherlands)
Type
Published Article
Journal
Osteoarthritis and Cartilage
Publisher
Elsevier
Publication Date
May 01, 2017
Volume
25
Issue
5
Pages
647–653
Identifiers
DOI: 10.1016/j.joca.2016.12.006
PMID: 27940216
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To examine the proportion of isolated patellofemoral osteoarthritis (PFOA) compared to tibiofemoral osteoarthritis (TFOA) in middle-aged participants with early osteoarthritis (OA) symptoms of the knee; to describe the natural course of PFOA compared with that of TFOA and to identify whether patients with PFOA have a different phenotype compared to patients with TFOA, or with combined PFOA and TFOA (combined osteoarthritis (COA)). Participants with early OA symptoms of the knee were selected, completed questionnaires, underwent physical examination, and had knee radiographs at baseline, and at 2 and 5 years follow-up. Based on radiographs, participants were classified as having isolated TFOA, isolated PFOA, COA, or no radiographic OA. Multivariate logistic regression was used to identify participant characteristics associated with a specific group of OA at 2 years follow-up. The cohort comprised 845 participants (mean age 55.9 years). At baseline, 116 had PFOA, none had TFOA or COA. Of these 116 participants, 66.3% had developed COA at 5 years follow-up. At 2 years follow-up, PFOA, TFOA and COA were present in 77 (10.8%), 39 (5.5%) and 83 (11.6%) participants, respectively. Multivariate regression analyses at 2 years follow-up showed that participants with radiographic PFOA or TFOA were not significantly different from each other with respect to signs and symptoms. These results suggest that OA is more likely to start in the patellofemoral joint and then progress to COA in individuals with symptoms of early knee OA. No differences in TFOA and PFOA phenotypes were determined with respect to signs and symptoms. Copyright © 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Report this publication

Statistics

Seen <100 times