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Incidence of mast cells in oral squamous cell carcinoma: a short study.

Authors
  • Anuradha, A
  • Kiran Kumar Naik, B
  • Vijay Srinivas, G
  • Devi, Ramisetty Sabitha
  • Puneet, H K
Type
Published Article
Journal
Journal of oncology
Publication Date
Jan 01, 2014
Volume
2014
Pages
614291–614291
Identifiers
DOI: 10.1155/2014/614291
PMID: 24587802
Source
Medline
License
Unknown

Abstract

Mast cells are regarded as complex and multifunctional cells, playing a significant role in immunopathology and a substantial role in tumor angiogenesis. Angiogenesis is a complex process that is tightly regulated by various growth factors in which mast cells act directly by releasing angiogenic factors and henceforth promoting tumor growth and metastasis. The aim of this study is to evaluate the number of mast cells in tissue sections of oral squamous cell carcinoma (OSCC) in comparison with normal mucosa. A total of 40 cases (20 OSCC and 20 normal mucosa) were stained with 1% toluidine blue and the quantitative analysis was done by using light microscope under 400x magnification. A significant increase in the mast cell count was observed in the sections of OSCC when compared to normal mucosa suggesting their contributing role in tumor growth and progression.

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