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Incidence of atopic conditions in people with psoriasis: a population-based analysis

Authors
  • Kirsten, Natalia1
  • Mohr, Nicole1
  • Maul, Julia-Tatjana2
  • Augustin, Matthias1
  • 1 University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, Hamburg, Germany , Hamburg (Germany)
  • 2 University Hospital Zurich, Gloriastraße 31, Zurich, 8091, Switzerland , Zurich (Switzerland)
Type
Published Article
Journal
European Journal of Dermatology
Publisher
John Libbey Eurotext
Publication Date
Jan 01, 2021
Volume
31
Issue
1
Pages
60–64
Identifiers
DOI: 10.1684/ejd.2021.3963
Source
Springer Nature
Keywords
License
Yellow

Abstract

BackgroundLarge-scale data on the association between psoriasis and atopic diseases are scarce.ObjectivesTo evaluate the concomitant prevalence of atopic conditions and psoriasis.Materials & MethodsIn this cross-sectional study, employees between 16 and 70 years of age were examined in more than 400 German companies by dermatologists, between 2006 and 2014. Two different definitions of atopic conditions were applied: “current atopic condition” (point prevalence) and “current or previous atopic condition” (lifetime prevalence). Bivariate comparisons as well as logistic regression analyses controlling for age and sex were performed.ResultsIn total, 90,265 persons were included in the study; 58.5% male; mean age: 43.2 ± 10.7 years. Point prevalence for psoriasis was 2.0% (n = 1,788), and lifetime prevalence of atopic conditions was 32.7% (n = 29,501). Atopic conditions were significantly less frequent (29.6%, n = 530) in persons with psoriasis compared to those without psoriasis (32.7%, n = 28,917; OR = 0.865; CI: 0.781–0.959). Concurrent and prior atopic conditions were observed in 13.7% (n = 245) of persons with psoriasis versus 15.6% without psoriasis (n =13,835; OR = 0.857; CI: 0.748–0.981). Controlling for age and sex, significant differences were found between persons with and without psoriasis for symptomatic atopic conditions such as hypersensitivity to pollen (OR = 0.864; CI: 0.748–0.997) and animal epithelia (OR = 0.764; CI: 0.609–0.958).ConclusionEven though the prevalence of atopic diseases is less frequent in individuals with psoriasis than in those without psoriasis, this study suggests that atopic conditions such as atopic dermatitis may also play a relevant role in psoriasis.

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