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Inactivity and Skeletal Muscle Metabolism: A Vicious Cycle in Old Age

Authors
  • Rezuş, Elena1
  • Burlui, Alexandra1
  • Cardoneanu, Anca1
  • Rezuş, Ciprian
  • Codreanu, Cătălin
  • Pârvu, Mirela
  • Rusu Zota, Gabriela
  • Tamba, Bogdan Ionel
  • 1 (A.C.)
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
Jan 16, 2020
Volume
21
Issue
2
Identifiers
DOI: 10.3390/ijms21020592
PMID: 31963330
PMCID: PMC7014434
Source
PubMed Central
Keywords
License
Green

Abstract

Aging is an inevitable and gradually progressive process affecting all organs and systems. The musculoskeletal system makes no exception, elderly exhibit an increased risk of sarcopenia (low muscle mass),dynapenia (declining muscle strength), and subsequent disability. Whereas in recent years the subject of skeletal muscle metabolic decline in the elderly has been gathering interest amongst researchers, as well as medical professionals, there are many challenges yet to be solved in order to counteract the effects of aging on muscle function efficiently. Noteworthy, it has been shown that aging individuals exhibit a decline in skeletal muscle metabolism, a phenomenon which may be linked to a number of predisposing (risk) factors such as telomere attrition, epigenetic changes, mitochondrial dysfunction, sedentary behavior (leading to body composition alterations), age-related low-grade systemic inflammation (inflammaging), hormonal imbalance, as well as a hypoproteic diet (unable to counterbalance the repercussions of the age-related increase in skeletal muscle catabolism). The present review aims to discuss the relationship between old age and muscle wasting in an effort to highlight the modifications in skeletal muscle metabolism associated with aging and physical activity.

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