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In Vivo Acquisition of High-Level Resistance to Imipenem in Escherichia coli

Authors
Publisher
American Society for Microbiology
Publication Date
Source
PMC
Keywords
  • Bacteriology
Disciplines
  • Biology

Abstract

Four clonally related Escherichia coli strains were isolated successively from bile duct of a girl suffering from sclerosing cholangitis. One of them, selected after an imipenem-containing regimen, was resistant to carbapenems and to broad-spectrum cephalosporins due to a plasmid-mediated cephalosporinase, CMY-2, and the lack of outer membrane proteins OmpF and OmpC.

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