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In Vitro Activity of TD-6424 against Staphylococcus aureus

Authors
  • John L. Pace
  • Kevin Krause
  • Deborah Johnston
  • Dmitri Debabov
  • Terry Wu
  • Lesley Farrington
  • Cassie Lane
  • Deborah L. Higgins
  • Burt Christensen
  • J. Kevin Judice
  • Koné Kaniga
Publisher
American Society for Microbiology
Publication Date
Nov 01, 2003
Source
PMC
Keywords
Disciplines
  • Philosophy
License
Unknown

Abstract

TD-6424, a rapidly bactericidal agent with multiple mechanisms of action, is more potent in vitro and more rapidly bactericidal than currently available agents against methicillin-susceptible and methicillin-resistant Staphylococcus aureus. TD-6424 produces a postantibiotic effect with a duration of 4 to 6 h against these organisms. The results suggest potential efficacy against susceptible and resistant strains of S. aureus.

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