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In Vitro Activity of Caspofungin (MK-0991) against Candida albicans Clinical Isolates Displaying Different Mechanisms of Azole Resistance

Authors
  • Stefano P. Bachmann
  • Thomas F. Patterson
  • José L. López-Ribot
Publisher
American Society for Microbiology
Publication Date
Jun 01, 2002
Source
PMC
Keywords
License
Unknown

Abstract

Caspofungin inhibits the synthesis of 1,3-β-d-glucan, a key step in fungal cell wall biosynthesis. Here we report on its potent in vitro activity (MIC at which 90% of the isolates tested are inhibited = 1 μg per ml of RPMI medium) against 32 Candida albicans fluconazole-susceptible and -resistant clinical isolates irrespective of the underlying resistance mechanism (alterations in ERG11 and/or upregulation of MDR and CDR genes encoding efflux pumps) and provide further evidence that caspofungin is not a substrate for multidrug transporters.

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