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Impulsivity in heroin-dependent individuals: structural and functional abnormalities within frontostriatal circuits.

Authors
  • Wang, Shicong1, 2
  • Zhang, Min1, 2
  • Liu, Shuang1, 2
  • Xu, Yan1, 2
  • Shao, Ziqiang1, 2
  • Chen, Longmao1, 2
  • Li, Jun1, 2
  • Yang, Wenhan3
  • Liu, Jun4
  • Yuan, Kai5, 6
  • 1 School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, People's Republic of China. , (China)
  • 2 Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, Shaanxi, People's Republic of China. , (China)
  • 3 Department of Radiology, Second Xiangya Hospital of Central South University, Changsha, Hunan, China. , (China)
  • 4 Department of Radiology, Second Xiangya Hospital of Central South University, Changsha, Hunan, China. [email protected] , (China)
  • 5 School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, People's Republic of China. [email protected] , (China)
  • 6 Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, Shaanxi, People's Republic of China. [email protected] , (China)
Type
Published Article
Journal
Brain Imaging and Behavior
Publisher
Springer-Verlag
Publication Date
Oct 01, 2021
Volume
15
Issue
5
Pages
2454–2463
Identifiers
DOI: 10.1007/s11682-020-00445-w
PMID: 33528803
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

High levels of impulsivity are a risk factor for the initiation of heroin use and a core behavioral characteristic of heroin dependence. Impulsivity also contributes to the maintenance of drug use and hinders effective therapy. Here we sought to identify neuroimaging markers of impulsivity in heroin-dependent individuals (HDI), with a focus on the nucleus accumbens (NAc), a key region implicated in impulsivity and drug addiction generally. Volume and resting-state functional connectivity (RSFC) differences of the bilateral NAc were investigated between 21 HDI and 21 age-, gender-, nicotine-, alcohol-matched healthy controls (HC). The neuroimaging results were then correlated with the Barratt Impulsivity Scales (BIS-11). Higher motor impulsivity (t = 2.347, p = 0.0253) and larger right NAc volume (F (1,38) = 4.719, p = 0.036) was observed in HDI. The right NAc volume was positively correlated with BIS total (r = 0.6196, p = 0.0239) /motor (r = 0.5921, p = 0.0330) scores in HC and BIS motor (r = 0.5145, p = 0.0170) score in HDI. A negative correlation was found between RSFC of the right NAc-bilateral superior frontal gyrus (SFG) and motor impulsivity in HDI (left: r=-0.6537, p = 0.0013; right: r=-0.6167, p = 0.0029) and HC (left: r=-0.6490,p = 0.0164; right: r=-0.6993, p = 0.0078). We aimed to reveal novel multimodality neuroimaging biomarkers of the higher impulsivity in HDI by focusing on the NAc and corresponding functional circuits. Higher motor impulsivity was observed in HDI. Furthermore, the volume of the right NAc and the RSFC strength of right NAc-SFG could be neuroimaging biomarkers for the severity of impulsivity in HDI. These potential biomarkers could be a target for novel treatments in HDI. © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.

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