The project PANOPTIS, funded by the European Commission under the H2020 Programme, aims at increasing the resilience of the transport infrastructures (focusing on roads) and ensuring reliable network availability under unfavourable conditions, such as extreme weather, landslides, and earthquakes. The main target is to combine downscaled climate change scenarios (applied to road infrastructures) with structural and geotechnical simulation tools and with actual data from a multi-sensor network (terrestrial and airborne-based), so as to provide the operators with an integrated tool able to support more effective management of their infrastructures at planning, maintenance and operation level. During the first stage of the project, the consortium will develop advanced technologies to monitor and control transport infrastructures, such as a Geotechnical and Structural Simulation Tool (SGSA) to predict structural and geotechnical risks in road infrastructures; drone-technologies applied to road upkeep and incident management; improved computer vision and machine learning techniques for damage diagnosis of infrastructure, and early warning systems to help operators identify and communicate emerging systemic risks. At the same time, experts in climate modelling, will analyse the possible short and long term effects of climate change on transport infrastructure (e.g. flooding, heavier snows). All the information from the different sensors, models and applications will be integrated and processed through a unique Resilience Assessment Platform that will support operators in the introduction of adaptation and mitigation strategies based on multi-risk scenarios. During the second stage of the project, ACCIONA Engineering will implement the developed technologies and methodologies in a section of the Spanish A-2 motorway, in the province of Guadalajara. PANOPTIS integrated Platform will help optimize the management and maintenance of the Ministry of Public Works' concession for a 77.5-km section, all in collaboration with ACCIONA Infrastructure Maintenance (AMISA) and ACCIONA Concessions. In parallel, PANOPTIS platform will also be implemented in a section of 62 Km of a Greek motorway, renowned for its seismic activity. The trials in Greece hosted by the operator Egnatia Odos will integrate the motorway that serves the Airport of Thessaloniki. So the scenario will integrate a modal transfer segment.