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Improving the estimation of the death rate of infected cells from time course data during the acute phase of virus infections: application to acute HIV-1 infection in a humanized mouse model.

Authors
  • Ikeda, Hiroki
  • de Boer, Rob J
  • Sato, Kei
  • Morita, Satoru
  • Misawa, Naoko
  • Koyanagi, Yoshio
  • Aihara, Kazuyuki
  • Iwami, Shingo1
  • 1 Department of Biology, Faculty of Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, Fukuoka, Japan. siwa[email protected] , (Japan)
Type
Published Article
Journal
Theoretical biology & medical modelling
Publication Date
May 21, 2014
Volume
11
Pages
22–22
Identifiers
DOI: 10.1186/1742-4682-11-22
PMID: 24885827
Source
Medline
License
Unknown

Abstract

The new models provided much better estimates than the previous model because they more precisely capture the de novo infection process. Both models describe the acute phase of HIV-1 infected humanized mice reasonably well, and we estimated an average death rate of infected cells of 0.61 and 0.61, an average exponential growth rate of 0.69 and 0.76, and an average basic reproduction number of 2.30 and 2.38 in the RQS model and the PWR model, respectively. These estimates are fairly close to those obtained in humans.

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