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Role of Selenium and Vitamins E and B9 in the Alleviation of Bovine Mastitis during the Periparturient Period.

Authors
  • Khan, Muhammad Zahoor1, 2
  • Ma, Yulin1
  • Xiao, Jianxin1
  • Chen, Tianyu1
  • Ma, Jiaying1
  • Liu, Shuai1
  • Wang, Yajing1
  • Khan, Adnan3
  • Alugongo, Gibson Maswayi1
  • Cao, Zhijun1
  • 1 Beijing Engineering Technology Research Center of Raw Milk Quality and Safety Control, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. , (China)
  • 2 Faculty of Veterinary and Animal Sciences, University of Agriculture, Dera Ismail Khan 29220, Pakistan. , (Pakistan)
  • 3 Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China. , (China)
Type
Published Article
Journal
Antioxidants
Publisher
MDPI AG
Publication Date
Mar 29, 2022
Volume
11
Issue
4
Identifiers
DOI: 10.3390/antiox11040657
PMID: 35453342
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Mastitis (inflammation of the mammary gland) commonly occurs in dairy cattle during the periparturient period (transition period), in which dairy cattle experience physiological and hormonal changes and severe negative energy balance, followed by oxidative stress. To maintain successful lactation and combat negative energy balance (NEB), excessive fat mobilization occurs, leading to overproduction of reactive oxygen species (ROS). Excessive fat mobilization also increases the concentrations of nonesterified fatty acids (NEFA) and β-hydroxybutyric acid (BHB) during the periparturient period. In addition, the excessive utilization of oxygen by cellular respiration in the mammary causes abnormal production of oxidative stress (OS). OS impairs the immunity and anti-inflammatory efficiency of periparturient dairy cattle, increasing their susceptibility to mastitis. To alleviate oxidative stress and subsequent mastitis, antioxidants are supplemented to dairy cattle from an external source. Extensive studies have been conducted on the supplementation of selenium (Se) and vitamins E and B9 to mitigate mastitis during the transition period in dairy cattle. Altogether, in the current review, we discuss the research development on bovine mastitis and its major causes, with special emphasis on oxidative stress during the transition period. Moreover, we discuss the antioxidant, immunoregulatory, and anti-inflammatory properties of Se and vitamins E and B9 and their role in the control of bovine mastitis in periparturient dairy cattle.

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