Affordable Access

deepdyve-link
Publisher Website

Improvement of the Immunochromatographic NG-Test Carba 5 Assay for the Detection of IMP Variants Previously Undetected

Authors
  • Volland, Hervé
  • Girlich, Delphine
  • Laguide, Marine
  • Gonzalez, Camille
  • Paris, Virginie
  • Laroche, Maxime
  • Oueslati, Saoussen
  • Dortet, Laurent
  • Simon, Stéphanie
  • Naas, Thierry
Type
Published Article
Journal
Antimicrobial Agents and Chemotherapy
Publisher
American Society for Microbiology
Publication Date
Dec 20, 2019
Volume
64
Issue
1
Identifiers
DOI: 10.1128/AAC.01940-19
PMID: 31685459
PMCID: PMC7187612
Source
PubMed Central
Keywords
License
Unknown

Abstract

Here, we evaluated the immunochromatographic assay NG-Test Carba 5v2 (NG-Biotech), with improved IMP variant detection on 31 IMP producers, representing the different branches of the IMP phylogeny, including 32 OXA-48, 19 KPC, 12 VIM, 14 NDM, and 13 multiple carbapenemase producers (CPs), 13 CPs that were not targeted, and 13 carbapenemase-negative isolates. All tested IMP variants were accurately detected without impairing detection of the other carbapenemases. Thus, NG-Test Carba 5v2 is now well adapted to countries with high IMP prevalence and to the epidemiology of CP- Pseudomonas aeruginosa , where IMPs are most frequently detected.

Report this publication

Statistics

Seen <100 times