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Improvement of cryo-EM maps by density modification

Authors
  • Terwilliger, Thomas C.1, 2
  • Ludtke, Steven J.3
  • Read, Randy J.4
  • Adams, Paul D.5, 6
  • Afonine, Pavel V.5
  • 1 Los Alamos National Laboratory, Los Alamos, NM, USA , Los Alamos (United States)
  • 2 New Mexico Consortium, Los Alamos, NM, USA , Los Alamos (United States)
  • 3 Baylor College of Medicine, Houston, TX, USA , Houston (United States)
  • 4 Cambridge Institute for Medical Research, Cambridge, UK , Cambridge (United Kingdom)
  • 5 Lawrence Berkeley National Laboratory, Berkeley, CA, USA , Berkeley (United States)
  • 6 University of California Berkeley, Berkeley, CA, USA , Berkeley (United States)
Type
Published Article
Journal
Nature Methods
Publisher
Springer Nature
Publication Date
Aug 17, 2020
Volume
17
Issue
9
Pages
923–927
Identifiers
DOI: 10.1038/s41592-020-0914-9
Source
Springer Nature
License
Yellow

Abstract

A method based on maximum likelihood density modification, adapted from X-ray crystallography, improves cryo-EM maps.

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