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Improvement of 8-arm maze performance in aged Fischer 344 rats with 3,4-diaminopyridine.

Authors
  • Davis, H P
  • Idowu, A
  • Gibson, G E
Type
Published Article
Journal
Experimental aging research
Publication Date
Jan 01, 1983
Volume
9
Issue
3
Pages
211–214
Identifiers
PMID: 6641784
Source
Medline
License
Unknown

Abstract

Short-term memory of a spatial task by male Fischer 344 rats at 3, 12, and 24 months of age was examined in a radial 8-arm maze. Performance by 24 month old rats was significantly poorer than that of 3 or 12 month old rats. 3,4-Diaminopyridine (1000 pmole/kg), a compound that stimulates acetylcholine release, significantly improved 8-arm maze performance by 24 month old rats. Thus, an age-related deficit in short-term memory for a spatial task can be ameliorated by a compound that stimulates acetylcholine release.

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