Affordable Access

Publisher Website

The important role of central sensitization in chronic musculoskeletal pain seen in different rheumatic diseases.

  • Guler, Mehmet Akif1
  • Celik, Omer Faruk2
  • Ayhan, Fikriye Figen2, 3
  • 1 Department of Physical Medicine and Rehabilitation, Gaziosmanpasa Taksim Training and Research Hospital, Mevlana District, 884. Street No: 23, 34255 Gaziosmanpasa, Istanbul, Turkey. [email protected] , (Turkey)
  • 2 Department of Physical Medicine and Rehabilitation, Divisions of Rheumatology, Pain Medicine, Health Sciences University, Ankara Training and Research Hospital, Ankara, Turkey. , (Turkey)
  • 3 Department of Physical Therapy and Rehabilitation, Usak University, High School of Health Sciences, Usak, Turkey. , (Turkey)
Published Article
Clinical Rheumatology
Publication Date
Nov 18, 2019
DOI: 10.1007/s10067-019-04749-1
PMID: 31446538


This study explored the role of central sensitization (CS) pain in patients with various rheumatic diseases using the CS inventory (CSI). A total of 193 patients of mean age 50.72 ± 9.65 years were included; they were divided into four different groups in terms of their rheumatic diseases. Patients with rheumatoid arthritis (RA), spondyloarthropathy (SpA), osteoarthritis (OA), and fibromyalgia syndrome (FMS) were evaluated in tertiary care rheumatology/pain medicine settings. Disease duration and activity, the Bath Ankylosing Spondylitis Disease Activity Index, the Disease Activity Score-28, and pain severity (evaluated using a visual analog scale) were assessed, and the Turkish version of the CSI administered. CS syndromes were present in almost half the patients (45% of SpA, 41% of RA, 62% of OA, and 94% of FMS patients). We found no significant relationship between disease activity and the CSI-A scores in SpA or RA patients (p = 0.731 and p = 0.390, respectively). As expected, the CSI-A scores were highest in the FMS group (p = 0.000), but were similar in the other groups (p < 0.05). CS-related syndromes (CSI-B conditions) were present at similar frequencies in the RA, SpA, and OA groups, but were less common in the FMS group (p = 0.000). The CSI usefully detects CS pain in patients with rheumatic diseases. Treatment of such pain can enhance the quality of daily life in patients with rheumatic diseases.Key Point• Central sensitization pain is common in patients with rheumatic diseases including rheumatoid arthritis, spondyloarthropathies, and osteoarthritis.

Report this publication


Seen <100 times