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The importance of vitamin D levels in autoimmune diseases.

Authors
  • Marques, Cláudia Diniz Lopes
  • Dantas, Andréa Tavares
  • Fragoso, Thiago Sotero
  • Duarte, Angela Luzia Branco Pinto
Type
Published Article
Journal
Revista Brasileira de Reumatologia
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2010
Volume
50
Issue
1
Pages
67–80
Identifiers
PMID: 21125142
Source
Medline
License
Unknown

Abstract

In addition to its role in calcium homeostasis, it is believed that the active form of vitamin D has immunomodulatory effects on cells of the immune system, particularly T lymphocytes, as well as on the production and action of several cytokines. The interaction of vitamin D with the immune system has been the target of a growing number of publications in recent years. Current studies have linked the deficiency of vitamin D with different autoimmune diseases, including insulin-dependent diabetes mellitus (IDDM), multiple sclerosis (MS), inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA). This article reviews the physiology and immunomodulatory role of vitamin D, emphasizing its involvement in rheumatic diseases such as SLE and RA.

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