Respiratory tract infections are a real public health problem, and the few studies of African data make difficult the definition of a probabilistic rational therapeutic approach. The present study from May 2006 to June 2007 included 107 strains of Streptococcus pneu-moniae and 94 strains of Streptococcus pyogenes. A single isolate was collected by topic, and the minimum inhibitory concentration (MIC) has been made by the E test method; 201 strains from 115 adults and 86 children were included in the study. From 107 strains of S. pneumoniae, 24 were from children; and from 94 strains of S. pyogenes, 62 came from child. From antibiotics susceptibility of S. pyogenes, 100% were sensitive to penicillin G, with MIC between 0.064 and 0.128; 20 were resistant to erythromycin; and 100% were sensitive to levofloxacin, chloramphenicol, amoxicillin, cefotaxime, and ceftriaxone. From S. pneumoniae, 95.3% were sensitive to penicillin G and 4.7% were intermediate ; 19.3% were resistant to erythromycin; 100% were sensitive to levofloxacin, cefotaxime amoxicillin, and ceftriaxone.