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The importance of lysozyme for the viscosity of sputum from patients with chronic obstructive lung disease.

Authors
Type
Published Article
Journal
Scandinavian journal of clinical and laboratory investigation
Publication Date
Volume
40
Issue
8
Pages
727–731
Identifiers
PMID: 7280551
Source
Medline
License
Unknown

Abstract

Addition of lysozyme (1 g/l) to sputum from patients with chronic obstructive lung disease increased the viscosity of the material significantly. The effect was prevented by addition of salt (LiCl) in the high concentration (0.25 mol/l). The sole addition of salt decreased the viscosity of native sputum. These results together with our earlier [5] studies of the interaction between the positively charged lysozyme and the negatively charged mucin molecules in model systems, indicate that lysozyme acts as a cross-linking agent in mucus by an electrostatic mechanism. Lysozyme is thus, at least partly, responsible for building up a macromolecular network giving mucus its characteristic gel-like properties.

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